Effects of vitamin d replacement combined with Graves’ disease therapy: a retrospective cohort study

Abstract

Background/aim: In Graves’ disease (GD), an autoimmune disease, antibodies targeting the TSH receptor cause the production of excessive amounts of thyroid hormone. A significant association has been reported between low 25(OH) Vitamin D3 (VitD) levels and various autoimmune disorders. Therefore, this study aimed to investigate the effects of VitD deficiency and replacement therapy on laboratory and clinical parameters in GD patients.Methods:Fourty GD and 37 healthy control patients were included in this study. Patients with GD were divided into two groups, and the first group was given only antithyroid treatment (n:18), and the second group was given antithyroid treatment plus VitD replacement (n:22). Clinical and laboratory data of all participants were compared at the time of diagnosis and 3 months after treatment.Results: Baseline serum VitD levels in patients with GD were significantly lower than the baseline serum VitD levels of the control group (16.1±9.9 ng/ml vs 22.2±8.5 ng/ml, p