Rethinking multiple sclerosis therapy beyond clinical phenotypes

Maria Pia Sormani, Heinz Wiendl, Xavier Montalban, Jiwon Oh

doi:10.1093/brain/awag273

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Rethinking multiple sclerosis therapy beyond clinical phenotypes

Maria Pia Sormani, Heinz Wiendl, Xavier Montalban, Jiwon Oh

Brain · 2026-11-04 · 149 (11) · 3703-3707

DOI: 10.1093/brain/awag273 ↗

Abstract Bibliographic details

Abstract

Sormani et al. argue that multiple sclerosis should be viewed as a biological continuum rather than distinct clinical forms. Evidence from recent trials suggests that therapies targeting shared biological mechanisms can slow disability progression across the disease spectrum, supporting a shift away from traditional classifications.

Bibliographic details

Authors: Maria Pia Sormani, Heinz Wiendl, Xavier Montalban, Jiwon Oh
Journal: Brain
Year of publication: 2026
Volume / Issue: 149 / 11
Pages: 3703-3707
Publisher: Oxford University Press (OUP)
DOI: 10.1093/brain/awag273
ISSN: 0006-8950; 1460-2156
Source: Crossref

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