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Rethinking multiple sclerosis therapy beyond clinical phenotypes
Brain · 2026-11-04 · 149 (11) · 3703-3707
DOI: 10.1093/brain/awag273 ↗Abstract
Sormani et al. argue that multiple sclerosis should be viewed as a biological continuum rather than distinct clinical forms. Evidence from recent trials suggests that therapies targeting shared biological mechanisms can slow disability progression across the disease spectrum, supporting a shift away from traditional classifications.